[HTML][HTML] The tweety Gene Family: From Embryo to Disease

RR Nalamalapu, M Yue, AR Stone… - Frontiers in Molecular …, 2021 - frontiersin.org
… history of tweety genes exists for vertebrates, the tweety homologs have … increased cell
aggregation and impaired cell proliferation, … TTYH2 in colon cancer consistently suggest TTYH2

[HTML][HTML] TTYH1 and TTYH2 serve as LRRC8A-independent volume-regulated anion channels in cancer cells

Y Bae, A Kim, CH Cho, D Kim, HG Jung, SS Kim, J Yoo… - Cells, 2019 - mdpi.com
Drosophila melanogaster tweety homologue 1 and 2 (TTYH1 and … and TTYH2 are upregulated
in glioblastoma cells and coloncancer cells, TTYH1 and TTYH2 regulate cell proliferation

[HTML][HTML] Elevated expression of Tweety homologue 3 predicts poor clinical outcomes in ovarian cancer

J Zhou, Y Xu, X Chen, F Chen, J Zhang, X Zhu - Journal of Cancer, 2021 - ncbi.nlm.nih.gov
… The tweety homologs form a large gene family that encode … up-regulated in colon
cancer tissues 18 . Silence of TTYH2 by transfecting siRNA markedly inhibited proliferation

[HTML][HTML] Surface expression of TTYH2 is attenuated by direct interaction with β-COP

J Ryu, DG Kim, YS Lee, Y Bae, A Kim, N Park… - BMB …, 2019 - ncbi.nlm.nih.gov
melanogaster gene tweety (1). Three members of the TTYH family (… that up-regulated
expression of TTYH2 mRNA expression has been observed in renal cancer and colon cancer cells (…

[HTML][HTML] Structures of tweety homolog proteins TTYH2 and TTYH3 reveal a Ca2+-dependent switch from intra- to intermembrane dimerization

B Li, CM Hoel, SG Brohawn - Nature communications, 2021 - nature.com
… The founding member, Drosophila melanogaster tweety (TTY), was named after a … is
upregulated in renal cell carcinoma 2 , colon carcinomas 11 , and … aggregation 11 . TTYH1 is …

Upregulation of TTYH3 promotes epithelial-to-mesenchymal transition through Wnt/β-catenin signaling and inhibits apoptosis in cholangiocarcinoma

W Xue, B Dong, Y Zhao, Y Wang, C Yang, Y Xie, Z Niu… - Cellular Oncology, 2021 - Springer
Tweety homolog 3 (TTYH3) is a member of the tweety family … renal cell carcinomas [18, 19],
and downregulation of TTYH2 … to inhibit EMT in colorectal cancer by downregulating the Wnt/…

[PDF][PDF] Integrated Bioinformatics Revealed 2 Novel Prognostic Biomarkers in Colorectal Cancer

H Li, L Liu, Y Jiang, H Jiang, C Niu, J Xia, Z Liu… - Int. J. Clin. Exp …, 2021 - e-century.us
TTYH2, a human homologue of the drosophila melanogasterTTYH2, a human homologue
of the drosophila melanogaster gene tweety, is up-regulated in colon carcinoma and …

[HTML][HTML] The TTYH3/MK5 Positive Feedback Loop regulates Tumor Progression via GSK3-β/β-catenin signaling in HCC

Y Wang, Y Xie, B Dong, W Xue, S Chen… - … Journal of Biological …, 2022 - ncbi.nlm.nih.gov
… and clinical significance of tweety homolog 3 (TTYH3) in … TTYH2 was found to be
overexpressed in renal 20 and colon … is upregulated in brain and colon cancer 33 . In the present …

Upregulated TTYH2 expression is critical for the invasion and migration of U2OS human osteosarcoma cell lines

DK Moon, YJ Bae, GR Jeong, CH Cho… - … and biophysical research …, 2019 - Elsevier
… , was found to inhibit proliferation and cell cycle progression in … of TTYH2 has been implicated
in renal and colon cancers [13… cells, we examined whether the silencing of TTYH2 gene

TTYH3, a potential prognosis biomarker associated with immune infiltration and immunotherapy response in lung cancer

Z Wei, X Zeng, Y Lei, H He, M Jamal, C Zhang… - International …, 2022 - Elsevier
… TTYH3 was up-regulated in lung cancerTTYH2 is the second member of the TTYHs family
and found to be overexpressed in several cancers like osteosarcoma [19], colon carcinoma